16 Day/16 Night Cruises out of San Diego, California

Are you looking for 16 day cruises that leave from San Diego, CA? As of today - July 18, 2025 - there are just 2 such cruise options. These cruise options are offered by just one cruise line - Holland America (total of 2 sailings, 1 on Eurodam and 1 on Nieuw Amsterdam).

In the following table you can see all 16 day cruises that depart from San Diego sorted by departure date.
Nieuw Amsterdam October 2, 2026
Oct. 2, 2026
From
$2,609
$/Day:
$163
Duration:
16 Nights
Region:
Panama Canal
Depart:
San Diego
Arrive:
Ft. Lauderdale
Ship:
Nieuw Amsterdam
Itinerary:
San Diego to Ft. Lauderdale
Eurodam October 8, 2026
Oct. 8, 2026
From
$2,549
$/Day:
$159
Duration:
16 Nights
Region:
Panama Canal
Depart:
San Diego
Arrive:
Ft. Lauderdale
Ship:
Eurodam
Itinerary:
San Diego to Ft. Lauderdale