16 Day/16 Night Cruises out of San Diego, California

Are you looking for 16 day cruises that leave from San Diego, CA? As of today - August 13, 2026 - there are 7 such cruise options. These cruise options are offered by three cruise lines - Holland America (total of 5 sailings, 2 on Eurodam, 2 on Koningsdam and 1 on Nieuw Amsterdam), Norwegian (NCL) (just 1 sailing on Norwegian Star) and Princess (just 1 sailing on Island Princess).

In the following table you can see all 16 day cruises that depart from San Diego sorted by departure date.
Nieuw Amsterdam October 2, 2026
Oct. 2, 2026
From
$2,309
per person
$/Day:
$145
Duration:
16 Nights
Region:
Panama Canal
Depart:
San Diego
Arrive:
Ft. Lauderdale
Ship:
Nieuw Amsterdam
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Nieuw Amsterdam October 2, 2026
Eurodam October 8, 2026
Oct. 8, 2026
From
$1,699
per person
$/Day:
$107
Duration:
16 Nights
Region:
Panama Canal
Depart:
San Diego
Arrive:
Ft. Lauderdale
Ship:
Eurodam
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Eurodam October 8, 2026
Island Princess January 29, 2027
Jan. 29, 2027
From
$2,159
per person
$/Day:
$135
Duration:
16 Nights
Region:
Panama Canal
Depart:
San Diego
Arrive:
Ft. Lauderdale
Ship:
Island Princess
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Island Princess January 29, 2027
Norwegian Star February 13, 2027
Feb. 13, 2027
From
$1,959
per person
$/Day:
$123
Duration:
16 Nights
Region:
Panama Canal
Depart:
San Diego
Arrive:
Miami
Ship:
Norwegian Star
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Norwegian Star February 13, 2027
Eurodam October 7, 2027
Oct. 7, 2027
From
$2,769
per person
$/Day:
$174
Duration:
16 Nights
Region:
Panama Canal
Depart:
San Diego
Arrive:
Ft. Lauderdale
Ship:
Eurodam
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Eurodam October 7, 2027
Koningsdam December 23, 2027
Dec. 23, 2027
From
$2,729
per person
$/Day:
$171
Duration:
16 Nights
Region:
Mexico
Depart:
San Diego
Arrive:
San Diego
Ship:
Koningsdam
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Koningsdam December 23, 2027
Koningsdam December 30, 2027
Dec. 30, 2027
From
$2,504
per person
$/Day:
$157
Duration:
16 Nights
Region:
Mexico
Depart:
San Diego
Arrive:
San Diego
Ship:
Koningsdam
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Koningsdam December 30, 2027