16 Day/16 Night Cruises out of San Diego, California

Are you looking for 16 day cruises that leave from San Diego, CA? As of today - October 23, 2025 - there are just 2 such cruise options. These cruise options are offered by just one cruise line - Holland America (total of 2 sailings, 1 on Eurodam and 1 on Nieuw Amsterdam).

In the following table you can see all 16 day cruises that depart from San Diego sorted by departure date.