16 Day/16 Night Cruises out of San Diego, California

Are you looking for 16 day cruises that leave from San Diego, CA? As of today - November 22, 2025 - there are just 3 such cruise options. These cruise options are offered by two cruise lines - Holland America (total of 2 sailings, 1 on Eurodam and 1 on Nieuw Amsterdam) and Princess (just 1 sailing on Island Princess).

In the following table you can see all 16 day cruises that depart from San Diego sorted by departure date.
Nieuw Amsterdam October 2, 2026
Oct. 2, 2026
From
$2,189
per person
$/Day:
$137
Duration:
16 Nights
Region:
Panama Canal
Depart:
San Diego
Arrive:
Ft. Lauderdale
Ship:
Nieuw Amsterdam
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Nieuw Amsterdam October 2, 2026
Eurodam October 8, 2026
Oct. 8, 2026
From
$2,219
per person
$/Day:
$139
Duration:
16 Nights
Region:
Panama Canal
Depart:
San Diego
Arrive:
Ft. Lauderdale
Ship:
Eurodam
Select
Eurodam October 8, 2026
Island Princess January 29, 2027
Jan. 29, 2027
From
$1,849
per person
$/Day:
$116
Duration:
16 Nights
Region:
Panama Canal
Depart:
San Diego
Arrive:
Ft. Lauderdale
Ship:
Island Princess
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Island Princess January 29, 2027