16 Day/16 Night Cruises out of San Diego, California

Are you looking for 16 day cruises that leave from San Diego, CA? As of today - September 28, 2026 - there are 5 such cruise options. These cruise options are offered by three cruise lines - Holland America (total of 3 sailings, 2 on Koningsdam and 1 on Eurodam), Norwegian (NCL) (just 1 sailing on Norwegian Star) and Princess (just 1 sailing on Island Princess).

In the following table you can see all 16 day cruises that depart from San Diego sorted by departure date.
Island Princess January 29, 2027
From
$2,199
per person
$/Day:
$138
Duration:
16 Nights
Region:
Panama Canal
Depart:
San Diego
Arrive:
Ft. Lauderdale
Ship:
Island Princess
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Island Princess January 29, 2027
Norwegian Star February 13, 2027
From
$1,939
per person
$/Day:
$122
Duration:
16 Nights
Region:
Panama Canal
Depart:
San Diego
Arrive:
Miami
Ship:
Norwegian Star
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Norwegian Star February 13, 2027
Eurodam October 7, 2027
From
$2,769
per person
$/Day:
$174
Duration:
16 Nights
Region:
Panama Canal
Depart:
San Diego
Arrive:
Ft. Lauderdale
Ship:
Eurodam
Select
Eurodam October 7, 2027
Koningsdam December 23, 2027
From
$2,739
per person
$/Day:
$172
Duration:
16 Nights
Region:
Mexico
Depart:
San Diego
Arrive:
San Diego
Ship:
Koningsdam
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Koningsdam December 23, 2027
Koningsdam December 30, 2027
From
$2,514
per person
$/Day:
$158
Duration:
16 Nights
Region:
Mexico
Depart:
San Diego
Arrive:
San Diego
Ship:
Koningsdam
Select
Koningsdam December 30, 2027