2 Day/2 Night Cruises out of San Diego, California

Are you looking for 2 day cruises that leave from San Diego, CA? As of today - December 11, 2025 - there is just 1 such cruise option. This cruise option is provided by Royal Caribbean on its Serenade of the Seas ship that was built in 2003.

In the following table you can see the 2 day cruise that departs from San Diego.
Serenade of the Seas October 2, 2026
Oct. 2, 2026
From
$349
per person
$/Day:
$175
Duration:
2 Nights
Region:
Mexico
Depart:
San Diego
Arrive:
San Diego
Ship:
Serenade of the Seas
Select
Serenade of the Seas October 2, 2026