2021 Cruises out of San Diego, California |
| There are 19 cruises that depart from San Diego, CA in the year 2021. Three cruise lines offer cruises that leave out of San Diego in 2021 - Holland America (total of 15 sailings, 10 on Koningsdam and 5 on Zuiderdam), Norwegian (NCL) (just 3 sailings, all of them on Norwegian Jewel) and Celebrity (just 1 sailing on Celebrity Millennium). You can see San Diego cruise schedule for 2021 in the table below. Be sure to look at the $/Day column to find cheap San Diego cruise deals in 2021. |
| Departure | Region | Itinerary | Ship | Days | Price | $/Day | Select |
| October 24 | Mexico | San Diego Round Trip | Koningsdam | 7 | $599 | $86 |  |
| October 27 | Panama Canal | San Diego to Ft. Lauderdale | Celebrity Millennium | 15 | $2,899 | $193 | |
| October 30 | Mexico | San Diego Round Trip | Zuiderdam | 7 | $599 | $86 | |
| October 31 | Pacific Coast | San Diego Round Trip | Koningsdam | 7 | $599 | $86 | |
| November 6 | Mexico | San Diego Round Trip | Zuiderdam | 12 | $1,199 | $100 | |
| November 7 | Pacific Coast | San Diego Round Trip | Koningsdam | 7 | $599 | $86 | |
| November 14 | Mexico | San Diego Round Trip | Koningsdam | 7 | $599 | $86 | |
| November 18 | Hawaii | San Diego Round Trip | Zuiderdam | 17 | $1,799 | $106 | |
| November 21 | Mexico | San Diego Round Trip | Koningsdam | 7 | $699 | $100 | |
| November 28 | Mexico | San Diego Round Trip | Koningsdam | 7 | $599 | $86 | |
| December 5 | Mexico | San Diego Round Trip | Koningsdam | 7 | $599 | $86 | |
| December 5 | Hawaii | San Diego Round Trip | Zuiderdam | 18 | $1,699 | $94 | |
| December 12 | Mexico | San Diego Round Trip | Koningsdam | 7 | $599 | $86 | |
| December 14 | Mexico | San Diego Round Trip | Norwegian Jewel | 5 | $475 | $95 | |
| December 19 | Mexico | San Diego Round Trip | Koningsdam | 7 | $999 | $143 | |
| December 19 | Mexico | San Diego Round Trip | Norwegian Jewel | 7 | $839 | $120 | |
| December 23 | Mexico | San Diego Round Trip | Zuiderdam | 10 | $1,799 | $180 | |
| December 26 | Mexico | San Diego Round Trip | Koningsdam | 7 | $1,099 | $157 | |
| December 26 | Mexico | San Diego Round Trip | Norwegian Jewel | 7 | $972 | $139 | |