2021 Cruises out of San Diego, California |
| There are 46 cruises that depart from San Diego, CA in the year 2021. Four cruise lines offer cruises that leave out of San Diego in 2021 - Carnival (total of 31 sailings, all of them on Carnival Miracle), Holland America (total of 13 sailings, among them 10 on Koningsdam and 2 on Zaandam), Celebrity (just 1 sailing on Celebrity Millennium) and Princess (just 1 sailing). You can see San Diego cruise schedule for 2021 in the table below. Be sure to look at the $/Day column to find cheap San Diego cruise deals in 2021. |
| Departure | Region | Itinerary | Ship | Days | Price | $/Day | Select |
| January 24 | Mexico | San Diego Round Trip | Carnival Miracle | 5 | $519 | $104 |  |
| January 29 | Mexico | San Diego Round Trip | Carnival Miracle | 3 | $339 | $113 | |
| February 1 | Mexico | San Diego Round Trip | Carnival Miracle | 5 | $509 | $102 | |
| February 6 | Mexico | San Diego Round Trip | Carnival Miracle | 5 | $509 | $102 | |
| February 11 | Mexico | San Diego Round Trip | Carnival Miracle | 4 | $469 | $117 | |
| February 15 | Mexico | San Diego Round Trip | Carnival Miracle | 5 | $529 | $106 | |
| February 20 | Hawaii | San Diego Round Trip | Carnival Miracle | 15 | $2,099 | $140 | |
| February 20 | Mexico | San Diego Round Trip | Koningsdam | 7 | $899 | $128 | |
| February 23 | Panama Canal | San Diego to Ft. Lauderdale | Zaandam | 18 | $2,649 | $147 | |
| February 27 | Mexico | San Diego Round Trip | Koningsdam | 7 | $899 | $128 | |
| March 6 | Mexico | San Diego Round Trip | Koningsdam | 7 | $899 | $128 | |
| March 7 | Mexico | San Diego Round Trip | Carnival Miracle | 6 | $619 | $103 | |
| March 10 | Panama Canal | San Diego to Ft. Lauderdale | Emerald Princess | 15 | $2,249 | $150 | |
| March 13 | Mexico | San Diego Round Trip | Carnival Miracle | 5 | $549 | $110 | |
| March 13 | Mexico | San Diego Round Trip | Koningsdam | 7 | $899 | $128 | |
| March 18 | Mexico | San Diego Round Trip | Carnival Miracle | 4 | $489 | $122 | |
| March 20 | Mexico | San Diego Round Trip | Koningsdam | 7 | $899 | $128 | |
| March 22 | Mexico | San Diego Round Trip | Carnival Miracle | 5 | $549 | $110 | |
| March 27 | Mexico | San Diego Round Trip | Koningsdam | 7 | $899 | $128 | |
| March 27 | Mexico | San Diego Round Trip | Carnival Miracle | 5 | $619 | $124 | |
| March 30 | Panama Canal | San Diego to Ft. Lauderdale | Zaandam | 18 | $2,539 | $141 | |
| April 1 | Mexico | San Diego Round Trip | Carnival Miracle | 4 | $489 | $122 | |
| April 3 | Mexico | San Diego Round Trip | Koningsdam | 7 | $899 | $128 | |
| April 5 | Hawaii | San Diego Round Trip | Carnival Miracle | 15 | $2,249 | $150 | |
| April 10 | Mexico | San Diego Round Trip | Koningsdam | 7 | $899 | $128 | |
| April 17 | Pacific Coast | San Diego Round Trip | Koningsdam | 7 | $799 | $114 | |
| April 20 | Mexico | San Diego Round Trip | Carnival Miracle | 4 | $439 | $110 | |
| April 21 | Pacific Coast | San Diego to Vancouver | Volendam | 7 | $899 | $128 | |
| April 24 | Pacific Coast | San Diego to Vancouver | Koningsdam | 7 | $799 | $114 | |
| October 3 | Mexico | San Diego Round Trip | Carnival Miracle | 5 | $464 | $93 | |
| October 8 | Mexico | San Diego Round Trip | Carnival Miracle | 3 | $369 | $123 | |
| October 11 | Mexico | San Diego Round Trip | Carnival Miracle | 5 | $464 | $93 | |
| October 16 | Hawaii | San Diego Round Trip | Carnival Miracle | 15 | $1,829 | $122 | |
| October 27 | Panama Canal | San Diego to Ft. Lauderdale | Celebrity Millennium | 15 | $2,371 | $158 | |
| October 31 | Mexico | San Diego Round Trip | Carnival Miracle | 5 | $449 | $90 | |
| November 5 | Mexico | San Diego Round Trip | Carnival Miracle | 3 | $354 | $118 | |
| November 8 | Mexico | San Diego Round Trip | Carnival Miracle | 5 | $449 | $90 | |
| November 13 | Mexico | San Diego Round Trip | Carnival Miracle | 5 | $449 | $90 | |
| November 18 | Mexico | San Diego Round Trip | Carnival Miracle | 4 | $409 | $102 | |
| November 22 | Mexico | San Diego Round Trip | Carnival Miracle | 5 | $629 | $126 | |
| November 27 | Hawaii | San Diego Round Trip | Carnival Miracle | 15 | $1,769 | $118 | |
| December 12 | Mexico | San Diego Round Trip | Carnival Miracle | 5 | $469 | $94 | |
| December 17 | Mexico | San Diego Round Trip | Carnival Miracle | 3 | $314 | $105 | |
| December 20 | Mexico | San Diego Round Trip | Carnival Miracle | 6 | $929 | $155 | |
| December 26 | Mexico | San Diego Round Trip | Carnival Miracle | 5 | $799 | $160 | |
| December 31 | Mexico | San Diego Round Trip | Carnival Miracle | 6 | $959 | $160 | |