2021 Cruises out of San Diego, California |
| There are 33 cruises that depart from San Diego, CA in the year 2021. Just two cruise lines offer cruises that leave out of San Diego in 2021 - Holland America (total of 24 sailings, among them 15 on Koningsdam, 4 on Rotterdam and 3 on Maasdam) and Carnival (total of 9 sailings, all of them on Carnival Miracle). You can see San Diego cruise schedule for 2021 in the table below. Be sure to look at the $/Day column to find cheap San Diego cruise deals in 2021. |
| Departure | Region | Itinerary | Ship | Days | Price | $/Day | Select |
| January 2 | Mexico | San Diego Round Trip | Koningsdam | 7 | $899 | $128 |  |
| January 4 | Mexico | San Diego Round Trip | Carnival Miracle | 5 | $579 | $116 | |
| January 9 | Mexico | San Diego Round Trip | Koningsdam | 7 | $899 | $128 | |
| January 9 | Hawaii | San Diego Round Trip | Carnival Miracle | 15 | $1,729 | $115 | |
| January 16 | Hawaii | San Diego Round Trip | Koningsdam | 17 | $2,199 | $129 | |
| January 20 | South America | San Diego Round Trip | Rotterdam | 32 | $3,399 | $106 | |
| January 20 | South America | San Diego to Lima | Rotterdam | 16 | $2,049 | $128 | |
| January 24 | Mexico | San Diego Round Trip | Carnival Miracle | 5 | $534 | $107 | |
| January 29 | Mexico | San Diego Round Trip | Carnival Miracle | 3 | $359 | $120 | |
| February 1 | Mexico | San Diego Round Trip | Carnival Miracle | 5 | $539 | $108 | |
| February 2 | Hawaii | San Diego Round Trip | Koningsdam | 18 | $2,299 | $128 | |
| February 2 | Hawaii | San Diego Round Trip | Koningsdam | 25 | $2,579 | $103 | |
| February 6 | Mexico | San Diego Round Trip | Carnival Miracle | 5 | $539 | $108 | |
| February 11 | Mexico | San Diego Round Trip | Carnival Miracle | 4 | $489 | $122 | |
| February 15 | Mexico | San Diego Round Trip | Carnival Miracle | 5 | $564 | $113 | |
| February 20 | Mexico | San Diego Round Trip | Koningsdam | 7 | $799 | $114 | |
| February 20 | Hawaii | San Diego Round Trip | Carnival Miracle | 15 | $1,759 | $117 | |
| February 21 | Hawaii | San Diego Round Trip | Rotterdam | 32 | $5,099 | $159 | |
| February 23 | Panama Canal | San Diego to Ft. Lauderdale | Zaandam | 18 | $2,399 | $133 | |
| February 27 | Mexico | San Diego Round Trip | Koningsdam | 7 | $849 | $121 | |
| March 6 | Mexico | San Diego Round Trip | Koningsdam | 7 | $849 | $121 | |
| March 13 | Mexico | San Diego Round Trip | Koningsdam | 7 | $849 | $121 | |
| March 20 | Mexico | San Diego Round Trip | Koningsdam | 7 | $849 | $121 | |
| March 25 | Panama Canal | San Diego to Ft. Lauderdale | Rotterdam | 16 | $2,099 | $131 | |
| March 27 | Mexico | San Diego Round Trip | Koningsdam | 7 | $799 | $114 | |
| March 30 | Panama Canal | San Diego to Ft. Lauderdale | Zaandam | 18 | $2,299 | $128 | |
| April 3 | Mexico | San Diego Round Trip | Koningsdam | 7 | $849 | $121 | |
| April 9 | Mexico | San Diego Round Trip | Maasdam | 10 | $1,329 | $133 | |
| April 9 | Mexico | San Diego to Vancouver | Maasdam | 14 | $1,399 | $100 | |
| April 10 | Mexico | San Diego Round Trip | Koningsdam | 7 | $849 | $121 | |
| April 17 | Pacific Coast | San Diego Round Trip | Koningsdam | 7 | $949 | $136 | |
| April 19 | Pacific Coast | San Diego to Vancouver | Maasdam | 4 | $399 | $100 | |
| April 24 | Pacific Coast | San Diego to Vancouver | Koningsdam | 7 | $699 | $100 | |