2021 Cruises out of San Diego, California |
| There are 60 cruises that depart from San Diego, CA in the year 2021. Four cruise lines offer cruises that leave out of San Diego in 2021 - Carnival (total of 33 sailings, all of them on Carnival Miracle), Holland America (total of 25 sailings, among them 15 on Koningsdam and 4 on Rotterdam), Celebrity (just 1 sailing on Celebrity Millennium) and Princess (just 1 sailing). You can see San Diego cruise schedule for 2021 in the table below. Be sure to look at the $/Day column to find cheap San Diego cruise deals in 2021. |
| Departure | Region | Itinerary | Ship | Days | Price | $/Day | Select |
| January 2 | Mexico | San Diego Round Trip | Koningsdam | 7 | $899 | $128 |  |
| January 4 | Mexico | San Diego Round Trip | Carnival Miracle | 5 | $579 | $116 | |
| January 9 | Hawaii | San Diego Round Trip | Carnival Miracle | 15 | $1,729 | $115 | |
| January 9 | Mexico | San Diego Round Trip | Koningsdam | 7 | $899 | $128 | |
| January 16 | Hawaii | San Diego Round Trip | Koningsdam | 17 | $2,199 | $129 | |
| January 20 | South America | San Diego Round Trip | Rotterdam | 32 | $3,599 | $112 | |
| January 20 | South America | San Diego to Lima | Rotterdam | 16 | $2,049 | $128 | |
| January 24 | Mexico | San Diego Round Trip | Carnival Miracle | 5 | $534 | $107 | |
| January 29 | Mexico | San Diego Round Trip | Carnival Miracle | 3 | $359 | $120 | |
| February 1 | Mexico | San Diego Round Trip | Carnival Miracle | 5 | $539 | $108 | |
| February 2 | Hawaii | San Diego Round Trip | Koningsdam | 25 | $2,579 | $103 | |
| February 2 | Hawaii | San Diego Round Trip | Koningsdam | 18 | $2,099 | $117 | |
| February 6 | Mexico | San Diego Round Trip | Carnival Miracle | 5 | $539 | $108 | |
| February 11 | Mexico | San Diego Round Trip | Carnival Miracle | 4 | $489 | $122 | |
| February 15 | Mexico | San Diego Round Trip | Carnival Miracle | 5 | $564 | $113 | |
| February 20 | Mexico | San Diego Round Trip | Koningsdam | 7 | $799 | $114 | |
| February 20 | Hawaii | San Diego Round Trip | Carnival Miracle | 15 | $1,759 | $117 | |
| February 21 | Hawaii | San Diego Round Trip | Rotterdam | 32 | $5,099 | $159 | |
| February 23 | Panama Canal | San Diego to Ft. Lauderdale | Zaandam | 18 | $2,399 | $133 | |
| February 27 | Mexico | San Diego Round Trip | Koningsdam | 7 | $849 | $121 | |
| March 6 | Mexico | San Diego Round Trip | Koningsdam | 7 | $849 | $121 | |
| March 7 | Mexico | San Diego Round Trip | Carnival Miracle | 6 | $739 | $123 | |
| March 10 | Panama Canal | San Diego to Ft. Lauderdale | Emerald Princess | 15 | $2,069 | $138 | |
| March 13 | Mexico | San Diego Round Trip | Koningsdam | 7 | $849 | $121 | |
| March 13 | Mexico | San Diego Round Trip | Carnival Miracle | 5 | $559 | $112 | |
| March 18 | Mexico | San Diego Round Trip | Carnival Miracle | 4 | $479 | $120 | |
| March 20 | Mexico | San Diego Round Trip | Koningsdam | 7 | $849 | $121 | |
| March 22 | Mexico | San Diego Round Trip | Carnival Miracle | 5 | $579 | $116 | |
| March 25 | Panama Canal | San Diego to Ft. Lauderdale | Rotterdam | 16 | $2,199 | $137 | |
| March 27 | Mexico | San Diego Round Trip | Carnival Miracle | 5 | $629 | $126 | |
| March 27 | Mexico | San Diego Round Trip | Koningsdam | 7 | $799 | $114 | |
| March 30 | Panama Canal | San Diego to Ft. Lauderdale | Zaandam | 18 | $2,299 | $128 | |
| April 1 | Mexico | San Diego Round Trip | Carnival Miracle | 4 | $499 | $125 | |
| April 3 | Mexico | San Diego Round Trip | Koningsdam | 7 | $849 | $121 | |
| April 5 | Hawaii | San Diego Round Trip | Carnival Miracle | 15 | $1,679 | $112 | |
| April 9 | Mexico | San Diego to Vancouver | Maasdam | 14 | $1,399 | $100 | |
| April 9 | Mexico | San Diego Round Trip | Maasdam | 10 | $1,329 | $133 | |
| April 10 | Mexico | San Diego Round Trip | Koningsdam | 7 | $849 | $121 | |
| April 17 | Pacific Coast | San Diego Round Trip | Koningsdam | 7 | $949 | $136 | |
| April 19 | Pacific Coast | San Diego to Vancouver | Maasdam | 4 | $399 | $100 | |
| April 20 | Mexico | San Diego Round Trip | Carnival Miracle | 4 | $449 | $112 | |
| April 21 | Pacific Coast | San Diego to Vancouver | Volendam | 7 | $799 | $114 | |
| April 24 | Pacific Coast | San Diego to Vancouver | Koningsdam | 7 | $699 | $100 | |
| October 3 | Mexico | San Diego Round Trip | Carnival Miracle | 5 | $519 | $104 | |
| October 8 | Mexico | San Diego Round Trip | Carnival Miracle | 3 | $399 | $133 | |
| October 11 | Mexico | San Diego Round Trip | Carnival Miracle | 5 | $519 | $104 | |
| October 16 | Hawaii | San Diego Round Trip | Carnival Miracle | 15 | $1,729 | $115 | |
| October 27 | Panama Canal | San Diego to Ft. Lauderdale | Celebrity Millennium | 15 | $1,791 | $119 | |
| October 31 | Mexico | San Diego Round Trip | Carnival Miracle | 5 | $529 | $106 | |
| November 5 | Mexico | San Diego Round Trip | Carnival Miracle | 3 | $379 | $126 | |
| November 8 | Mexico | San Diego Round Trip | Carnival Miracle | 5 | $519 | $104 | |
| November 13 | Mexico | San Diego Round Trip | Carnival Miracle | 5 | $519 | $104 | |
| November 18 | Mexico | San Diego Round Trip | Carnival Miracle | 4 | $439 | $110 | |
| November 22 | Mexico | San Diego Round Trip | Carnival Miracle | 5 | $699 | $140 | |
| November 27 | Hawaii | San Diego Round Trip | Carnival Miracle | 15 | $1,679 | $112 | |
| December 12 | Mexico | San Diego Round Trip | Carnival Miracle | 5 | $529 | $106 | |
| December 17 | Mexico | San Diego Round Trip | Carnival Miracle | 3 | $379 | $126 | |
| December 20 | Mexico | San Diego Round Trip | Carnival Miracle | 6 | $969 | $162 | |
| December 26 | Mexico | San Diego Round Trip | Carnival Miracle | 5 | $899 | $180 | |
| December 31 | Mexico | San Diego Round Trip | Carnival Miracle | 6 | $999 | $167 | |