2021 Cruises out of San Francisco, California |
| There are 45 cruises that depart from San Francisco, CA in the year 2021. Three cruise lines offer cruises that leave out of San Francisco in 2021 - Princess (total of 24 sailings, 23 on Ruby Princess and 1 on Emerald Princess), Carnival (total of 20 sailings, all of them on Carnival Miracle) and Holland America (just 1 sailing on Nieuw Amsterdam). You can see San Francisco cruise schedule for 2021 in the table below. Be sure to look at the $/Day column to find cheap San Francisco cruise deals in 2021. |
| Departure | Region | Itinerary | Ship | Days | Price | $/Day | Select |
| January 7 | Mexico | San Francisco Round Trip | Ruby Princess | 10 | $1,199 | $120 |  |
| January 17 | Hawaii | San Francisco Round Trip | Ruby Princess | 15 | $1,799 | $120 | |
| February 1 | Mexico | San Francisco Round Trip | Ruby Princess | 10 | $1,199 | $120 | |
| February 8 | Panama Canal | San Francisco to Ft. Lauderdale | Emerald Princess | 15 | $2,199 | $147 | |
| February 11 | Pacific Coast | San Francisco Round Trip | Ruby Princess | 5 | $579 | $116 | |
| March 3 | Hawaii | San Francisco Round Trip | Ruby Princess | 15 | $1,699 | $113 | |
| March 18 | Hawaii | San Francisco Round Trip | Ruby Princess | 15 | $1,799 | $120 | |
| April 2 | Hawaii | San Francisco Round Trip | Ruby Princess | 15 | $1,899 | $127 | |
| April 17 | Pacific Coast | San Francisco Round Trip | Ruby Princess | 7 | $829 | $118 | |
| April 24 | Pacific Coast | San Francisco Round Trip | Ruby Princess | 7 | $1,049 | $150 | |
| April 25 | Mexico | San Francisco Round Trip | Carnival Miracle | 4 | $409 | $102 | |
| April 29 | Mexico | San Francisco Round Trip | Carnival Miracle | 4 | $409 | $102 | |
| April 29 | Pacific Coast | San Francisco to Vancouver | Nieuw Amsterdam | 3 | $309 | $103 | |
| May 1 | Alaska | San Francisco Round Trip | Ruby Princess | 10 | $1,399 | $140 | |
| May 3 | Alaska | San Francisco Round Trip | Carnival Miracle | 10 | $1,049 | $105 | |
| May 11 | Alaska | San Francisco Round Trip | Ruby Princess | 10 | $1,499 | $150 | |
| May 13 | Mexico | San Francisco Round Trip | Carnival Miracle | 4 | $409 | $102 | |
| May 17 | Alaska | San Francisco Round Trip | Carnival Miracle | 10 | $1,079 | $108 | |
| May 21 | Alaska | San Francisco Round Trip | Ruby Princess | 10 | $1,499 | $150 | |
| May 27 | Mexico | San Francisco Round Trip | Carnival Miracle | 4 | $509 | $127 | |
| May 31 | Alaska | San Francisco Round Trip | Ruby Princess | 10 | $1,549 | $155 | |
| May 31 | Alaska | San Francisco Round Trip | Carnival Miracle | 10 | $1,119 | $112 | |
| June 10 | Alaska | San Francisco Round Trip | Carnival Miracle | 10 | $1,209 | $121 | |
| June 10 | Alaska | San Francisco Round Trip | Ruby Princess | 10 | $1,599 | $160 | |
| June 20 | Alaska | San Francisco Round Trip | Ruby Princess | 10 | $1,699 | $170 | |
| June 20 | Alaska | San Francisco Round Trip | Carnival Miracle | 11 | $1,449 | $132 | |
| June 30 | Alaska | San Francisco Round Trip | Ruby Princess | 10 | $1,749 | $175 | |
| July 1 | Mexico | San Francisco Round Trip | Carnival Miracle | 4 | $559 | $140 | |
| July 5 | Alaska | San Francisco Round Trip | Carnival Miracle | 10 | $1,299 | $130 | |
| July 10 | Alaska | San Francisco Round Trip | Ruby Princess | 10 | $1,749 | $175 | |
| July 15 | Mexico | San Francisco Round Trip | Carnival Miracle | 4 | $549 | $137 | |
| July 19 | Alaska | San Francisco Round Trip | Carnival Miracle | 10 | $1,299 | $130 | |
| July 20 | Alaska | San Francisco Round Trip | Ruby Princess | 10 | $1,749 | $175 | |
| July 29 | Mexico | San Francisco Round Trip | Carnival Miracle | 4 | $549 | $137 | |
| July 30 | Alaska | San Francisco Round Trip | Ruby Princess | 10 | $1,699 | $170 | |
| August 2 | Alaska | San Francisco Round Trip | Carnival Miracle | 10 | $1,289 | $129 | |
| August 9 | Alaska | San Francisco Round Trip | Ruby Princess | 10 | $1,649 | $165 | |
| August 12 | Alaska | San Francisco Round Trip | Carnival Miracle | 10 | $1,249 | $125 | |
| August 19 | Alaska | San Francisco Round Trip | Ruby Princess | 10 | $1,599 | $160 | |
| August 22 | Alaska | San Francisco Round Trip | Carnival Miracle | 11 | $1,329 | $121 | |
| August 29 | Alaska | San Francisco Round Trip | Ruby Princess | 10 | $1,499 | $150 | |
| September 2 | Mexico | San Francisco Round Trip | Carnival Miracle | 4 | $459 | $115 | |
| September 6 | Alaska | San Francisco Round Trip | Carnival Miracle | 10 | $1,139 | $114 | |
| September 8 | Alaska | San Francisco Round Trip | Ruby Princess | 10 | $1,599 | $160 | |
| September 16 | Hawaii | San Francisco Round Trip | Carnival Miracle | 16 | $1,839 | $115 | |