2021 Cruises out of San Francisco, California |
| There are 11 cruises that depart from San Francisco, CA in the year 2021. Only one cruise line offers cruises that leave out of San Francisco in 2021 - Princess (total of 11 sailings, 10 on Ruby Princess and 1 on Emerald Princess). You can see San Francisco cruise schedule for 2021 in the table below. Be sure to look at the $/Day column to find cheap San Francisco cruise deals in 2021. |
| Departure | Region | Itinerary | Ship | Days | Price | $/Day | Select |
| January 7 | Mexico | San Francisco Round Trip | Ruby Princess | 10 | $969 | $97 |  |
| January 17 | Hawaii | San Francisco Round Trip | Ruby Princess | 15 | $1,719 | $115 | |
| February 1 | Mexico | San Francisco Round Trip | Ruby Princess | 10 | $1,249 | $125 | |
| February 8 | Panama Canal | San Francisco to Ft. Lauderdale | Emerald Princess | 15 | $1,849 | $123 | |
| February 11 | Pacific Coast | San Francisco Round Trip | Ruby Princess | 5 | $599 | $120 | |
| February 16 | Hawaii | San Francisco Round Trip | Ruby Princess | 15 | $1,719 | $115 | |
| March 3 | Hawaii | San Francisco Round Trip | Ruby Princess | 15 | $1,719 | $115 | |
| March 18 | Hawaii | San Francisco Round Trip | Ruby Princess | 15 | $2,079 | $139 | |
| April 2 | Hawaii | San Francisco Round Trip | Ruby Princess | 15 | $1,719 | $115 | |
| April 17 | Pacific Coast | San Francisco Round Trip | Ruby Princess | 7 | $909 | $130 | |
| April 24 | Pacific Coast | San Francisco Round Trip | Ruby Princess | 7 | $1,239 | $177 | |