2022 Cruises out of San Diego, California |
| There are 26 cruises that depart from San Diego, CA in the year 2022. Three cruise lines offer cruises that leave out of San Diego in 2022 - Holland America (total of 20 sailings, among them 9 on Koningsdam, 7 on Zuiderdam and 2 on Noordam), Norwegian (NCL) (total of 5 sailings, all of them on Norwegian Jewel) and Celebrity (just 1 sailing on Celebrity Millennium). You can see San Diego cruise schedule for 2022 in the table below. Be sure to look at the $/Day column to find cheap San Diego cruise deals in 2022. |
| Departure | Region | Itinerary | Ship | Days | Price | $/Day | Select |
| January 30 | Panama Canal | San Diego to Ft. Lauderdale | Zuiderdam | 14 | $1,569 | $112 |  |
| February 2 | Hawaii | San Diego Round Trip | Koningsdam | 18 | $2,199 | $122 | |
| February 2 | Hawaii | San Diego Round Trip | Koningsdam | 25 | $2,709 | $108 | |
| February 20 | Mexico | San Diego Round Trip | Koningsdam | 7 | $669 | $96 | |
| February 27 | Mexico | San Diego Round Trip | Koningsdam | 7 | $449 | $64 | |
| February 27 | Hawaii | San Diego Round Trip | Zuiderdam | 35 | $5,899 | $169 | |
| March 6 | Mexico | San Diego Round Trip | Koningsdam | 7 | $449 | $64 | |
| March 13 | Mexico | San Diego Round Trip | Koningsdam | 7 | $449 | $64 | |
| March 20 | Pacific Coast | San Diego Round Trip | Koningsdam | 7 | $649 | $93 | |
| March 27 | Pacific Coast | San Diego Round Trip | Koningsdam | 7 | $649 | $93 | |
| April 3 | Pacific Coast | San Diego to Vancouver | Koningsdam | 7 | $649 | $93 | |
| April 3 | Mexico | San Diego Round Trip | Zuiderdam | 10 | $1,099 | $110 | |
| April 10 | Mexico | San Diego Round Trip | Norwegian Jewel | 7 | $636 | $91 | |
| April 13 | Mexico | San Diego to Vancouver | Zuiderdam | 14 | $1,199 | $86 | |
| April 13 | Mexico | San Diego Round Trip | Zuiderdam | 9 | $899 | $100 | |
| April 17 | Mexico | San Diego Round Trip | Norwegian Jewel | 5 | $399 | $80 | |
| April 22 | Pacific Coast | San Diego to Vancouver | Zuiderdam | 5 | $399 | $80 | |
| April 22 | Alaska | San Diego to Vancouver | Norwegian Jewel | 10 | $831 | $83 | |
| April 25 | Pacific Coast | San Diego to Vancouver | Eurodam | 4 | $339 | $85 | |
| April 26 | Pacific Coast | San Diego to Vancouver | Nieuw Amsterdam | 5 | $479 | $96 | |
| May 3 | Pacific Coast | San Diego to Vancouver | Celebrity Millennium | 10 | $1,219 | $122 | |
| October 3 | Pacific | San Diego Round Trip | Zuiderdam | 45 | $6,749 | $150 | |
| October 8 | Pacific | San Diego to Sydney | Noordam | 34 | $4,699 | $138 | |
| October 8 | Pacific | San Diego to Sydney | Noordam | 69 | $10,599 | $154 | |
| December 24 | Mexico | San Diego Round Trip | Norwegian Jewel | 7 | $1,052 | $150 | |
| December 31 | Mexico | San Diego Round Trip | Norwegian Jewel | 7 | $1,143 | $163 | |