2022 Cruises out of San Diego, California |
| There are 32 cruises that depart from San Diego, CA in the year 2022. Three cruise lines offer cruises that leave out of San Diego in 2022 - Holland America (total of 15 sailings, among them 9 on Koningsdam, 2 on Noordam and 2 on Zuiderdam), Princess (total of 15 sailings, all of them on Diamond Princess) and Norwegian (NCL) (just 2 sailings, both of them on Norwegian Jewel). You can see San Diego cruise schedule for 2022 in the table below. Be sure to look at the $/Day column to find cheap San Diego cruise deals in 2022. |
| Departure | Region | Itinerary | Ship | Days | Price | $/Day | Select |
| September 1 | Pacific Coast | San Diego Round Trip | Diamond Princess | 5 | $329 | $66 |  |
| September 6 | Mexico | San Diego Round Trip | Diamond Princess | 5 | $329 | $66 | |
| September 11 | Mexico | San Diego Round Trip | Diamond Princess | 7 | $459 | $66 | |
| September 18 | Pacific Coast | San Diego Round Trip | Diamond Princess | 7 | $549 | $78 | |
| September 25 | Pacific Coast | San Diego Round Trip | Diamond Princess | 7 | $619 | $88 | |
| October 2 | Mexico | San Diego Round Trip | Diamond Princess | 7 | $419 | $60 | |
| October 3 | Pacific | San Diego Round Trip | Zuiderdam | 45 | $6,549 | $146 | |
| October 8 | Panama Canal | San Diego to Ft. Lauderdale | Nieuw Amsterdam | 17 | $1,549 | $91 | |
| October 8 | Pacific | San Diego to Sydney | Noordam | 69 | $10,739 | $156 | |
| October 8 | Pacific | San Diego to Sydney | Noordam | 34 | $4,699 | $138 | |
| October 9 | Mexico | San Diego Round Trip | Diamond Princess | 7 | $429 | $61 | |
| October 13 | Panama Canal | San Diego to Ft. Lauderdale | Eurodam | 16 | $1,499 | $94 | |
| October 16 | Mexico | San Diego Round Trip | Diamond Princess | 7 | $429 | $61 | |
| October 23 | Hawaii | San Diego Round Trip | Diamond Princess | 16 | $1,099 | $69 | |
| November 5 | Pacific Coast | San Diego Round Trip | Koningsdam | 7 | $649 | $93 | |
| November 8 | Pacific Coast | San Diego Round Trip | Diamond Princess | 5 | $299 | $60 | |
| November 12 | Mexico | San Diego Round Trip | Koningsdam | 7 | $549 | $78 | |
| November 13 | Mexico | San Diego Round Trip | Diamond Princess | 7 | $569 | $81 | |
| November 17 | Panama Canal | San Diego to Ft. Lauderdale | Zuiderdam | 14 | $1,399 | $100 | |
| November 19 | Mexico | San Diego Round Trip | Koningsdam | 7 | $399 | $57 | |
| November 20 | Mexico | San Diego Round Trip | Diamond Princess | 7 | $719 | $103 | |
| November 26 | Mexico | San Diego Round Trip | Koningsdam | 7 | $449 | $64 | |
| November 27 | Mexico | San Diego Round Trip | Diamond Princess | 20 | $1,599 | $80 | |
| December 3 | Mexico | San Diego Round Trip | Koningsdam | 7 | $399 | $57 | |
| December 10 | Mexico | San Diego Round Trip | Koningsdam | 7 | $449 | $64 | |
| December 17 | Mexico | San Diego Round Trip | Diamond Princess | 10 | $1,299 | $130 | |
| December 17 | Mexico | San Diego Round Trip | Koningsdam | 5 | $299 | $60 | |
| December 22 | Mexico | San Diego Round Trip | Koningsdam | 7 | $849 | $121 | |
| December 24 | Mexico | San Diego Round Trip | Norwegian Jewel | 7 | $999 | $143 | |
| December 27 | Mexico | San Diego Round Trip | Diamond Princess | 10 | $949 | $95 | |
| December 29 | Mexico | San Diego Round Trip | Koningsdam | 9 | $1,249 | $139 | |
| December 31 | Mexico | San Diego Round Trip | Norwegian Jewel | 7 | $909 | $130 | |