2022 Cruises out of San Diego, California |
| There are 31 cruises that depart from San Diego, CA in the year 2022. Three cruise lines offer cruises that leave out of San Diego in 2022 - Holland America (total of 23 sailings, among them 11 on Koningsdam, 8 on Zuiderdam and 2 on Noordam), Norwegian (NCL) (total of 7 sailings, all of them on Norwegian Jewel) and Celebrity (just 1 sailing on Celebrity Millennium). You can see San Diego cruise schedule for 2022 in the table below. Be sure to look at the $/Day column to find cheap San Diego cruise deals in 2022. |
| Departure | Region | Itinerary | Ship | Days | Price | $/Day | Select |
| January 2 | Mexico | San Diego Round Trip | Koningsdam | 7 | $599 | $86 |  |
| January 2 | Panama Canal | San Diego to Ft. Lauderdale | Zuiderdam | 14 | $1,769 | $126 | |
| January 2 | Mexico | San Diego Round Trip | Norwegian Jewel | 7 | $594 | $85 | |
| January 9 | Panama Canal | San Diego to Colon | Norwegian Jewel | 11 | $839 | $76 | |
| January 16 | Hawaii | San Diego Round Trip | Koningsdam | 17 | $1,919 | $113 | |
| January 30 | Panama Canal | San Diego to Ft. Lauderdale | Zuiderdam | 14 | $1,809 | $129 | |
| February 2 | Hawaii | San Diego Round Trip | Koningsdam | 18 | $2,329 | $129 | |
| February 2 | Hawaii | San Diego Round Trip | Koningsdam | 25 | $2,799 | $112 | |
| February 20 | Mexico | San Diego Round Trip | Koningsdam | 7 | $599 | $86 | |
| February 27 | Mexico | San Diego Round Trip | Koningsdam | 7 | $599 | $86 | |
| February 27 | Hawaii | San Diego Round Trip | Zuiderdam | 35 | $4,999 | $143 | |
| March 6 | Mexico | San Diego Round Trip | Koningsdam | 7 | $599 | $86 | |
| March 13 | Mexico | San Diego Round Trip | Koningsdam | 7 | $599 | $86 | |
| March 20 | Pacific Coast | San Diego Round Trip | Koningsdam | 7 | $784 | $112 | |
| March 27 | Pacific Coast | San Diego Round Trip | Koningsdam | 7 | $629 | $90 | |
| April 3 | Mexico | San Diego Round Trip | Zuiderdam | 10 | $1,099 | $110 | |
| April 3 | Pacific Coast | San Diego to Vancouver | Koningsdam | 7 | $629 | $90 | |
| April 10 | Mexico | San Diego Round Trip | Norwegian Jewel | 7 | $692 | $99 | |
| April 13 | Mexico | San Diego to Vancouver | Zuiderdam | 14 | $1,239 | $89 | |
| April 13 | Mexico | San Diego Round Trip | Zuiderdam | 9 | $999 | $111 | |
| April 17 | Mexico | San Diego Round Trip | Norwegian Jewel | 5 | $622 | $124 | |
| April 22 | Pacific Coast | San Diego to Vancouver | Zuiderdam | 5 | $399 | $80 | |
| April 22 | Alaska | San Diego to Vancouver | Norwegian Jewel | 10 | $832 | $83 | |
| April 25 | Pacific Coast | San Diego to Vancouver | Eurodam | 4 | $409 | $102 | |
| April 26 | Pacific Coast | San Diego to Vancouver | Nieuw Amsterdam | 5 | $599 | $120 | |
| May 3 | Pacific Coast | San Diego to Vancouver | Celebrity Millennium | 10 | $1,429 | $143 | |
| October 3 | Pacific | San Diego Round Trip | Zuiderdam | 45 | $6,649 | $148 | |
| October 8 | Pacific | San Diego to Sydney | Noordam | 34 | $4,109 | $121 | |
| October 8 | Pacific | San Diego to Sydney | Noordam | 69 | $10,099 | $146 | |
| December 24 | Mexico | San Diego Round Trip | Norwegian Jewel | 7 | $944 | $135 | |
| December 31 | Mexico | San Diego Round Trip | Norwegian Jewel | 7 | $1,035 | $148 | |