2022 Cruises out of San Francisco, California |
| There are 28 cruises that depart from San Francisco, CA in the year 2022. Three cruise lines offer cruises that leave out of San Francisco in 2022 - Princess (total of 14 sailings, all of them on Ruby Princess), Carnival (total of 11 sailings, all of them on Carnival Miracle) and Cunard (just 3 sailings, all of them on Queen Elizabeth). You can see San Francisco cruise schedule for 2022 in the table below. Be sure to look at the $/Day column to find cheap San Francisco cruise deals in 2022. |
| Departure | Region | Itinerary | Ship | Days | Price | $/Day | Select |
| June 29 | Alaska | San Francisco Round Trip | Ruby Princess | 10 | $1,049 | $105 |  |
| June 30 | Mexico | San Francisco Round Trip | Carnival Miracle | 5 | $557 | $111 | |
| July 5 | Alaska | San Francisco Round Trip | Carnival Miracle | 10 | $1,059 | $106 | |
| July 9 | Alaska | San Francisco Round Trip | Ruby Princess | 10 | $1,049 | $105 | |
| July 15 | Alaska | San Francisco Round Trip | Carnival Miracle | 10 | $1,044 | $104 | |
| July 19 | Alaska | San Francisco Round Trip | Ruby Princess | 10 | $1,099 | $110 | |
| July 24 | Panama Canal | San Francisco to Barcelona | Queen Elizabeth | 36 | $3,799 | $106 | |
| July 24 | Panama Canal | San Francisco to Barcelona | Queen Elizabeth | 29 | $3,199 | $110 | |
| July 24 | Panama Canal | San Francisco to Ft. Lauderdale | Queen Elizabeth | 16 | $1,999 | $125 | |
| July 25 | Alaska | San Francisco Round Trip | Carnival Miracle | 10 | $1,739 | $174 | |
| July 29 | Alaska | San Francisco Round Trip | Ruby Princess | 10 | $999 | $100 | |
| August 4 | Mexico | San Francisco Round Trip | Carnival Miracle | 4 | $359 | $90 | |
| August 8 | Alaska | San Francisco Round Trip | Carnival Miracle | 10 | $1,769 | $177 | |
| August 8 | Alaska | San Francisco Round Trip | Ruby Princess | 10 | $949 | $95 | |
| August 18 | Mexico | San Francisco Round Trip | Carnival Miracle | 4 | $319 | $80 | |
| August 18 | Alaska | San Francisco Round Trip | Ruby Princess | 10 | $999 | $100 | |
| August 22 | Alaska | San Francisco Round Trip | Carnival Miracle | 10 | $3,439 | $344 | |
| August 28 | Alaska | San Francisco Round Trip | Ruby Princess | 10 | $999 | $100 | |
| September 1 | Mexico | San Francisco Round Trip | Carnival Miracle | 4 | $304 | $76 | |
| September 5 | Alaska | San Francisco Round Trip | Carnival Miracle | 10 | $859 | $86 | |
| September 7 | Alaska | San Francisco Round Trip | Ruby Princess | 10 | $949 | $95 | |
| September 15 | Hawaii | San Francisco Round Trip | Carnival Miracle | 15 | $2,939 | $196 | |
| September 17 | Pacific Coast | San Francisco Round Trip | Ruby Princess | 7 | $499 | $71 | |
| September 24 | Pacific Coast | San Francisco Round Trip | Ruby Princess | 7 | $499 | $71 | |
| October 1 | Pacific Coast | San Francisco Round Trip | Ruby Princess | 7 | $549 | $78 | |
| October 8 | Hawaii | San Francisco Round Trip | Ruby Princess | 15 | $1,099 | $73 | |
| October 23 | Hawaii | San Francisco Round Trip | Ruby Princess | 15 | $1,249 | $83 | |
| November 7 | Hawaii | San Francisco Round Trip | Ruby Princess | 15 | $1,379 | $92 | |