2022 Cruises out of San Francisco, California |
| There are 42 cruises that depart from San Francisco, CA in the year 2022. Just two cruise lines offer cruises that leave out of San Francisco in 2022 - Princess (total of 23 sailings, all of them on Ruby Princess) and Carnival (total of 19 sailings, all of them on Carnival Miracle). You can see San Francisco cruise schedule for 2022 in the table below. Be sure to look at the $/Day column to find cheap San Francisco cruise deals in 2022. |
| Departure | Region | Itinerary | Ship | Days | Price | $/Day | Select |
| January 6 | Mexico | San Francisco Round Trip | Ruby Princess | 10 | $849 | $85 |  |
| January 16 | Hawaii | San Francisco Round Trip | Ruby Princess | 15 | $1,499 | $100 | |
| January 31 | Mexico | San Francisco Round Trip | Ruby Princess | 10 | $849 | $85 | |
| February 10 | Hawaii | San Francisco Round Trip | Ruby Princess | 15 | $1,499 | $100 | |
| February 25 | Panama Canal | San Francisco to Ft. Lauderdale | Ruby Princess | 15 | $1,399 | $93 | |
| March 27 | Hawaii | San Francisco Round Trip | Ruby Princess | 15 | $1,649 | $110 | |
| April 11 | Pacific Coast | San Francisco Round Trip | Ruby Princess | 5 | $419 | $84 | |
| April 16 | Pacific Coast | San Francisco Round Trip | Ruby Princess | 7 | $649 | $93 | |
| April 23 | Pacific Coast | San Francisco Round Trip | Ruby Princess | 7 | $949 | $136 | |
| April 28 | Mexico | San Francisco Round Trip | Carnival Miracle | 4 | $359 | $90 | |
| April 30 | Alaska | San Francisco Round Trip | Ruby Princess | 10 | $999 | $100 | |
| May 2 | Alaska | San Francisco Round Trip | Carnival Miracle | 10 | $929 | $93 | |
| May 10 | Alaska | San Francisco Round Trip | Ruby Princess | 10 | $1,199 | $120 | |
| May 12 | Mexico | San Francisco Round Trip | Carnival Miracle | 4 | $359 | $90 | |
| May 16 | Alaska | San Francisco Round Trip | Carnival Miracle | 10 | $929 | $93 | |
| May 20 | Alaska | San Francisco Round Trip | Ruby Princess | 10 | $1,049 | $105 | |
| May 26 | Mexico | San Francisco Round Trip | Carnival Miracle | 5 | $599 | $120 | |
| May 30 | Alaska | San Francisco Round Trip | Ruby Princess | 10 | $1,249 | $125 | |
| May 31 | Alaska | San Francisco Round Trip | Carnival Miracle | 10 | $959 | $96 | |
| June 9 | Alaska | San Francisco Round Trip | Ruby Princess | 10 | $1,149 | $115 | |
| June 10 | Alaska | San Francisco Round Trip | Carnival Miracle | 10 | $1,019 | $102 | |
| June 19 | Alaska | San Francisco Round Trip | Ruby Princess | 10 | $1,249 | $125 | |
| June 20 | Alaska | San Francisco Round Trip | Carnival Miracle | 10 | $1,049 | $105 | |
| June 29 | Alaska | San Francisco Round Trip | Ruby Princess | 10 | $1,399 | $140 | |
| June 30 | Mexico | San Francisco Round Trip | Carnival Miracle | 5 | $619 | $124 | |
| July 5 | Alaska | San Francisco Round Trip | Carnival Miracle | 10 | $1,069 | $107 | |
| July 9 | Alaska | San Francisco Round Trip | Ruby Princess | 10 | $1,299 | $130 | |
| July 15 | Alaska | San Francisco Round Trip | Carnival Miracle | 10 | $1,099 | $110 | |
| July 19 | Alaska | San Francisco Round Trip | Ruby Princess | 10 | $1,449 | $145 | |
| July 25 | Alaska | San Francisco Round Trip | Carnival Miracle | 10 | $1,054 | $105 | |
| July 29 | Alaska | San Francisco Round Trip | Ruby Princess | 10 | $1,249 | $125 | |
| August 4 | Mexico | San Francisco Round Trip | Carnival Miracle | 4 | $499 | $125 | |
| August 8 | Alaska | San Francisco Round Trip | Carnival Miracle | 10 | $994 | $99 | |
| August 8 | Alaska | San Francisco Round Trip | Ruby Princess | 10 | $1,319 | $132 | |
| August 18 | Mexico | San Francisco Round Trip | Carnival Miracle | 4 | $449 | $112 | |
| August 18 | Alaska | San Francisco Round Trip | Ruby Princess | 10 | $1,149 | $115 | |
| August 22 | Alaska | San Francisco Round Trip | Carnival Miracle | 10 | $979 | $98 | |
| August 28 | Alaska | San Francisco Round Trip | Ruby Princess | 10 | $1,249 | $125 | |
| September 1 | Mexico | San Francisco Round Trip | Carnival Miracle | 4 | $439 | $110 | |
| September 5 | Alaska | San Francisco Round Trip | Carnival Miracle | 10 | $879 | $88 | |
| September 7 | Alaska | San Francisco Round Trip | Ruby Princess | 10 | $1,219 | $122 | |
| September 15 | Hawaii | San Francisco Round Trip | Carnival Miracle | 15 | $1,889 | $126 | |