2025 Cruises out of San Diego, California |
| There are 31 cruises that depart from San Diego, CA in the year 2025. Just two cruise lines offer cruises that leave out of San Diego in 2025 - Holland America (total of 30 sailings, among them 12 on Nieuw Amsterdam, 8 on Zaandam and 8 on Koningsdam) and Norwegian (NCL) (just 1 sailing on Norwegian Jade). You can see San Diego cruise schedule for 2025 in the table below. Be sure to look at the $/Day column to find cheap San Diego cruise deals in 2025. |
| Departure | Region | Itinerary | Ship | Days | Price | $/Day | Select |
| January 4 | Mexico | San Diego Round Trip | Koningsdam | 7 | $889 | $127 |  |
| January 4 | Hawaii | San Diego Round Trip | Koningsdam | 24 | $2,649 | $110 | |
| January 11 | Hawaii | San Diego Round Trip | Koningsdam | 17 | $1,909 | $112 | |
| January 28 | Hawaii | San Diego Round Trip | Koningsdam | 18 | $1,999 | $111 | |
| March 22 | Mexico | San Diego to Vancouver | Koningsdam | 14 | $1,664 | $119 | |
| March 22 | Mexico | San Diego Round Trip | Koningsdam | 7 | $974 | $139 | |
| March 29 | Hawaii | San Diego to Vancouver | Koningsdam | 24 | $2,629 | $110 | |
| April 12 | Mexico | San Diego Round Trip | Zaandam | 14 | $1,704 | $122 | |
| April 19 | Mexico | San Diego Round Trip | Zaandam | 14 | $1,079 | $77 | |
| April 26 | Mexico | San Diego Round Trip | Zaandam | 7 | $834 | $119 | |
| April 26 | Pacific Coast | San Diego to Vancouver | Eurodam | 6 | $859 | $143 | |
| April 30 | Pacific Coast | San Diego to Vancouver | Nieuw Amsterdam | 4 | $484 | $121 | |
| May 3 | Pacific Coast | San Diego to Vancouver | Zaandam | 4 | $419 | $105 | |
| September 29 | Hawaii | San Diego Round Trip | Zaandam | 51 | $7,404 | $145 | |
| October 4 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 14 | $1,229 | $88 | |
| October 9 | Panama Canal | San Diego to Ft. Lauderdale | Eurodam | 17 | $2,079 | $122 | |
| October 11 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 14 | $1,779 | $127 | |
| October 11 | Pacific Coast | San Diego Round Trip | Nieuw Amsterdam | 7 | $1,029 | $147 | |
| October 18 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 14 | $1,279 | $91 | |
| October 18 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 7 | $874 | $125 | |
| October 18 | Panama Canal | San Diego to Miami | Norwegian Jade | 14 | $1,449 | $104 | |
| October 21 | Pacific Coast | San Diego Round Trip | Koningsdam | 4 | $529 | $132 | |
| October 25 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 14 | $1,279 | $91 | |
| October 25 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 7 | $679 | $97 | |
| December 6 | Mexico | San Diego Round Trip | Zaandam | 12 | $1,079 | $90 | |
| December 6 | Hawaii | San Diego Round Trip | Zaandam | 29 | $3,104 | $107 | |
| December 9 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 11 | $1,039 | $94 | |
| December 18 | Hawaii | San Diego Round Trip | Zaandam | 17 | $2,509 | $148 | |
| December 20 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 14 | $1,929 | $138 | |
| December 20 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 7 | $1,184 | $169 | |
| December 27 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 7 | $1,274 | $182 | |
