There are 36 cruises that depart from San Diego, CA in the year 2025. Just two cruise lines offer cruises that leave out of San Diego in 2025 - Holland America (total of 28 sailings, among them 18 on Nieuw Amsterdam, 5 on Zaandam and 3 on Koningsdam) and Norwegian (NCL) (total of 8 sailings, all of them on Norwegian Jade).
You can see San Diego cruise schedule for 2025 in the table below. Be sure to look at the $/Day column to find cheap San Diego cruise deals in 2025.