There are 52 cruises that depart from San Diego, CA in the year 2026. Just two cruise lines offer cruises that leave out of San Diego in 2026 - Holland America (total of 39 sailings, among them 13 on Zaandam, 11 on Koningsdam and 8 on Nieuw Amsterdam) and Norwegian (NCL) (total of 13 sailings, 10 on Norwegian Jade and 3 on Norwegian Star).
You can see San Diego cruise schedule for 2026 in the table below. Be sure to look at the $/Day column to find cheap San Diego cruise deals in 2026.