4 Day/4 Night Cruises out of San Diego, California

Are you looking for 4 day cruises that leave from San Diego, CA? As of today - November 2, 2025 - there are 7 such cruise options. These cruise options are offered by two cruise lines - Holland America (total of 4 sailings, among them 1 on Zaandam, 1 on Eurodam and 1 on Koningsdam) and Royal Caribbean (just 3 sailings, all of them on Serenade of the Seas).

In the following table you can see all 4 day cruises that depart from San Diego sorted by departure date.
Eurodam April 20, 2026
Apr. 20, 2026
From
$399
per person
$/Day:
$100
Duration:
4 Nights
Region:
Pacific Coast
Depart:
San Diego
Arrive:
Vancouver
Ship:
Eurodam
Zaandam May 2, 2026
May. 2, 2026
From
$399
per person
$/Day:
$100
Duration:
4 Nights
Region:
Pacific Coast
Depart:
San Diego
Arrive:
Vancouver
Ship:
Zaandam
Serenade of the Seas October 11, 2026
Oct. 11, 2026
From
$497
per person
$/Day:
$125
Duration:
4 Nights
Region:
Mexico
Depart:
San Diego
Arrive:
San Diego
Ship:
Serenade of the Seas
Serenade of the Seas November 29, 2026
Nov. 29, 2026
From
$465
per person
$/Day:
$117
Duration:
4 Nights
Region:
Mexico
Depart:
San Diego
Arrive:
San Diego
Ship:
Serenade of the Seas
Serenade of the Seas December 6, 2026
Dec. 6, 2026
From
$465
per person
$/Day:
$117
Duration:
4 Nights
Region:
Mexico
Depart:
San Diego
Arrive:
San Diego
Ship:
Serenade of the Seas
Koningsdam April 3, 2027
Apr. 3, 2027
From
$494
per person
$/Day:
$124
Duration:
4 Nights
Region:
Pacific Coast
Depart:
San Diego
Arrive:
Vancouver
Ship:
Koningsdam
Nieuw Amsterdam April 28, 2027
Apr. 28, 2027
From
$514
per person
$/Day:
$129
Duration:
4 Nights
Region:
Pacific Coast
Depart:
San Diego
Arrive:
Vancouver
Ship:
Nieuw Amsterdam