4 Day/4 Night Cruises out of San Diego, California

Are you looking for 4 day cruises that leave from San Diego, CA? As of today - September 29, 2026 - there are 18 such cruise options. These cruise options are offered by two cruise lines - Royal Caribbean (total of 15 sailings, all of them on Serenade of the Seas) and Holland America (total of 3 sailings, 2 on Koningsdam and 1 on Nieuw Amsterdam).

In the following table you can see all 4 day cruises that depart from San Diego sorted by departure date.
Serenade of the Seas October 11, 2026
From
$454
per person
$/Day:
$114
Duration:
4 Nights
Region:
Mexico
Depart:
San Diego
Arrive:
San Diego
Ship:
Serenade of the Seas
Select
Serenade of the Seas October 11, 2026
Serenade of the Seas November 29, 2026
From
$260
per person
$/Day:
$65
Duration:
4 Nights
Region:
Mexico
Depart:
San Diego
Arrive:
San Diego
Ship:
Serenade of the Seas
Select
Serenade of the Seas November 29, 2026
Serenade of the Seas December 6, 2026
From
$320
per person
$/Day:
$80
Duration:
4 Nights
Region:
Mexico
Depart:
San Diego
Arrive:
San Diego
Ship:
Serenade of the Seas
Select
Serenade of the Seas December 6, 2026
Serenade of the Seas January 10, 2027
From
$320
per person
$/Day:
$80
Duration:
4 Nights
Region:
Mexico
Depart:
San Diego
Arrive:
San Diego
Ship:
Serenade of the Seas
Select
Serenade of the Seas January 10, 2027
Serenade of the Seas January 17, 2027
From
$382
per person
$/Day:
$96
Duration:
4 Nights
Region:
Mexico
Depart:
San Diego
Arrive:
San Diego
Ship:
Serenade of the Seas
Select
Serenade of the Seas January 17, 2027
Serenade of the Seas January 24, 2027
From
$319
per person
$/Day:
$80
Duration:
4 Nights
Region:
Mexico
Depart:
San Diego
Arrive:
San Diego
Ship:
Serenade of the Seas
Select
Serenade of the Seas January 24, 2027
Serenade of the Seas February 7, 2027
From
$297
per person
$/Day:
$75
Duration:
4 Nights
Region:
Mexico
Depart:
San Diego
Arrive:
San Diego
Ship:
Serenade of the Seas
Select
Serenade of the Seas February 7, 2027
Serenade of the Seas February 14, 2027
From
$321
per person
$/Day:
$81
Duration:
4 Nights
Region:
Mexico
Depart:
San Diego
Arrive:
San Diego
Ship:
Serenade of the Seas
Select
Serenade of the Seas February 14, 2027
Serenade of the Seas February 21, 2027
From
$319
per person
$/Day:
$80
Duration:
4 Nights
Region:
Mexico
Depart:
San Diego
Arrive:
San Diego
Ship:
Serenade of the Seas
Select
Serenade of the Seas February 21, 2027
Serenade of the Seas March 7, 2027
From
$352
per person
$/Day:
$88
Duration:
4 Nights
Region:
Mexico
Depart:
San Diego
Arrive:
San Diego
Ship:
Serenade of the Seas
Select
Serenade of the Seas March 7, 2027
Serenade of the Seas March 14, 2027
From
$331
per person
$/Day:
$83
Duration:
4 Nights
Region:
Mexico
Depart:
San Diego
Arrive:
San Diego
Ship:
Serenade of the Seas
Select
Serenade of the Seas March 14, 2027
Serenade of the Seas March 21, 2027
From
$340
per person
$/Day:
$85
Duration:
4 Nights
Region:
Mexico
Depart:
San Diego
Arrive:
San Diego
Ship:
Serenade of the Seas
Select
Serenade of the Seas March 21, 2027
Koningsdam April 3, 2027
From
$399
per person
$/Day:
$100
Duration:
4 Nights
Region:
Pacific Coast
Depart:
San Diego
Arrive:
Vancouver
Ship:
Koningsdam
OnBoard Credit:
$50 - $200
Select
Koningsdam April 3, 2027
Serenade of the Seas April 4, 2027
From
$449
per person
$/Day:
$113
Duration:
4 Nights
Region:
Mexico
Depart:
San Diego
Arrive:
San Diego
Ship:
Serenade of the Seas
OnBoard Credit:
$50
Select
Serenade of the Seas April 4, 2027
Serenade of the Seas April 11, 2027
From
$424
per person
$/Day:
$106
Duration:
4 Nights
Region:
Mexico
Depart:
San Diego
Arrive:
San Diego
Ship:
Serenade of the Seas
OnBoard Credit:
$50
Select
Serenade of the Seas April 11, 2027
Serenade of the Seas April 18, 2027
From
$424
per person
$/Day:
$106
Duration:
4 Nights
Region:
Mexico
Depart:
San Diego
Arrive:
San Diego
Ship:
Serenade of the Seas
OnBoard Credit:
$50
Select
Serenade of the Seas April 18, 2027
Nieuw Amsterdam April 28, 2027
From
$429
per person
$/Day:
$108
Duration:
4 Nights
Region:
Pacific Coast
Depart:
San Diego
Arrive:
Vancouver
Ship:
Nieuw Amsterdam
OnBoard Credit:
$50 - $200
Select
Nieuw Amsterdam April 28, 2027
Koningsdam April 8, 2028
From
$544
per person
$/Day:
$136
Duration:
4 Nights
Region:
Pacific Coast
Depart:
San Diego
Arrive:
Vancouver
Ship:
Koningsdam
Select
Koningsdam April 8, 2028