21 Day/21 Night Cruises out of San Diego, California

Are you looking for 21 day cruises that leave from San Diego, CA? As of today - August 18, 2026 - there is just 1 such cruise option. This cruise option is provided by Holland America on its Nieuw Amsterdam ship that was built in 2010.

In the following table you can see the 21 day cruise that departs from San Diego.
Nieuw Amsterdam October 12, 2027
Oct. 12, 2027
From
$2,784
per person
$/Day:
$133
Duration:
21 Nights
Region:
South America
Depart:
San Diego
Arrive:
San Antonio
Ship:
Nieuw Amsterdam
Select
Nieuw Amsterdam October 12, 2027